Automated synthesis of 5-[18F]fluoro-2′-deoxyuridine☆

Add time:09/02/2019    Source:sciencedirect.com

An automated synthesis system for the production of 5-[18F]fluoro-2′-deoxyuridine ([18F]FdUrd) has been developed for routine clinical use. The reaction process consists of addition of 18F2 to 3,5-di-O-acetyl-2′-deoxyuridine, hydrolysis of 18F-adduct and purification of [18F]FdUrd on tandem columns of ion retardation resin and alumina. These procedures are controlled by a microcomputer. The system provides about 30 mCi of [18F]FdUrd in a sterile and pyrogen-free aqueous solution with a radiochemical yield of 20% and a radiochemical purity of over 98% within 60 min after the 60-min irradiation with a current of 12 μA.

We also recommend Trading Suppliers and Manufacturers of 3,5'-Di-O-acetyl-2'-deoxyuridine (cas 13030-62-1). Pls Click Website Link as below: cas 13030-62-1 suppliers

Prev:pH-dependent self-assembly of amphiphilic poly(l-glutamic acid)-block-poly(lactic-co-glycolic acid) copolymers
Next:A mechanistical study on non-equilibrium reaction pathways in solid nitromethane (CH3NO2) and D3-nitromethane (CD3NO2) upon interaction with ionizing radiation)