Apoptotic activities of C2-ceramide and C2-dihydroceramide homologues against HL-60 cells
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Add time:09/02/2019 Source:sciencedirect.com
The apoptotic activities of non-natural ceramide homologues, C2-homo-ceramide, C2-homo-dihydroceramide, C2-bishomo-ceramide and C2-bishomo-dihydroceramide, were examined using human leukemia HL-60 cells. The apoptotic activity was in order of C2-ceramide>C2-homo-ceramide≈C2-bishomo-ceramide and the activities of the l-erythro- and d-erythro-ceramide homologues were similar. The morphological features of the cells, DNA fragmentations, proteolytic processing of pro-caspase-3 and the cleavage of PARP as the result of treatments with these homologues indicated that cell death was induced by apoptosis.
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