Synthesis of non-Natural C2-Homo-ceramide and its apoptotic activity against HL-60 cells
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Add time:09/05/2019 Source:sciencedirect.com
Non-natural ceramide analogues, C2-homo-ceramide and C2-homo-dihydroceramide, were prepared from l-aspartic acid via l-homo-serine. The apoptotic activities of the synthesized ceramide analogues were examined in HL-60 human leukemia cells. C2-homo- and C2-bishomo-ceramide indicate low but considerable apoptotic activities in comparison with C2-ceramide.
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