Chitosan/alginate complexes for vaginal delivery of Chlorhexidine digluconate (cas 18472-51-0)

Add time:09/06/2019    Source:sciencedirect.com

Chitosan/alginate complexes were prepared at different polycation/polyanion molar ratios and freeze-dried vaginal inserts were obtained for chlorhexidine digluconate local delivery in genital infections. Complex yield, FT-IR spectra, and TGA thermograms were studied to confirm the interaction between the two polyions. The influence of different complexes on physical handling, morphology, and drug distribution in the samples were evaluated by friability test, scanning electron microscopy (SEM), and energy dispersive X-ray spectroscopy (EDS), respectively. In vitro water-uptake, mucoadhesion and release tests were performed as well as microbiological tests toward pathogenic vaginal microorganisms. The results showed that the selection of suitable chitosan/alginate molar ratio and drug loading allowed modulate insert ability to hydrate, adhere to the mucosa, and release chlorhexidine digluconate. The insert containing an excess of alginate was found to be the best performing formulation and showed good antimicrobial activity toward the pathogens Candida albicans and Escherichia coli.

We also recommend Trading Suppliers and Manufacturers of Chlorhexidine digluconate (cas 18472-51-0). Pls Click Website Link as below: cas 18472-51-0 suppliers

Prev:Tracking of the degradation process of Chlorhexidine digluconate (cas 18472-51-0) and ethylenediaminetetraacetic acid in the presence of hyper-pure chlorine dioxide in endodontic disinfection
Next:Local facial atrophy and permanent anesthesia of right upper lip following subcutaneous extrusion of Chlorhexidine digluconate (cas 18472-51-0))