3-(2-Carboxy-ethyl)-4,6-DICHLORO-1H-INDOLE-2-CARBOXYLIC ACID (cas 18474-60-7): an allosteric inhibitor of fructose-1,6-bisphosphatase at the AMP site

Add time:09/03/2019    Source:sciencedirect.com

3-(2-Carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid (MDL-29951), an antagonist of the glycine site of the NMDA receptor, has been found to be an allosteric inhibitor of the enzyme fructose 1,6-bisphosphatase. The compound binds at the AMP regulatory site by X-ray crystallography. This represents a new approach to inhibition of fructose 1,6-bisphosphatase and serves as a lead for further drug design.

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