Effects of the isomeric forms of propranolol on central monoamine metabolism in regions of rat brain

Add time:09/07/2019    Source:sciencedirect.com

1.1. Rats were injected with d,l; 1- or d-propranolol, 50 mg/kg i.p.2.2. Levels of the monoamine metabolites 3-methoxy-4-hydroxyphenylglycol (MOPEG), homovanillic acid (HVA) and 5-hydroxy-indole-3-acetic acid (5-HIAA) were determined by mass fragmentography in regions of rat brain.3.3. After d,l; and 1-propranolol the MOPEG content in brain increased significantly. The HVA level was preferentially increased in a limbic brain region, the olfactory tubercle. The 5-HIAA content was diminished or unchanged irrespective of the isomeric forms of propranolol.4.4. The elevated levels of MOPEG and HVA after l-propranolol may be of relevance for the antipsychotic properties suggested for d,l-propranolol.

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