ArticleChronic propranolol treatment in developing rats: Acute and lasting effects on monoamines and beta-adrenergic receptors in the rat brain

Add time:09/08/2019    Source:sciencedirect.com

During early postnatal development rat pups were treated twice daily with the beta-adrenergic antagonist propranolol (15 mg/kg) in order to study the acute and long-lasting effects of early blockade of noradrenergic beta-mediated neurotransmission. Treatments from postnatal days 1–10 or days 11–20 did not induce alterations in the number of beta-adrenergic receptors as measured three days after the last injection, nor could lasting effects be shown at 60 days of age. The day 1–10 treatment, however, had a significant effect on the regional brain levels of noradrenaline (NA) and its metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG), measured 90 min after the last injection. The metabolite had increased by 40% in all brain regions examined. On day 60, the MHPG concentrations were still increased when compared to postnatally saline-treated animals. Propranolol treatment from day 11–20 only marginally increased MHPG on day 20 and induced no lasting differences. These results suggest that propranolol treatment during the first ten days of life produces a long-lasting increase in NA metabolism, possibly reflecting an increased neuronal NA turnover.

We also recommend Trading Suppliers and Manufacturers of 4-Methoxy Propranolol (cas 18507-09-0). Pls Click Website Link as below: cas 18507-09-0 suppliers

Prev:Effects of the isomeric forms of propranolol on central monoamine metabolism in regions of rat brain
Next:Short communicationThe effect of propranolol on blood pressure and central MOPEG concentration in the conscious spontaneously hypertensive rat)