Synthesis and anti-inflammatory activity of 3-(4′-geranyloxy-3′-methoxyphenyl)-2-trans propenoic acid and its ester derivatives

Add time:09/04/2019    Source:sciencedirect.com

Different esters of 3-(4′-geranyloxy-3′-methoxyphenyl)-2-trans propenoic acid (1), an anti-inflammatory principle of Acronychia baueri Schott (Rutaceae), were synthesized. Their topical anti-inflammatory activity was evaluated using the Croton oil ear test in mice as a model of acute inflammation. The activity of the paracetamol, guaiacol and hydroquinone esters of (1) was higher than that of the parent compound, being similar to that exerted by indomethacin, used as reference drug.

We also recommend Trading Suppliers and Manufacturers of 3-(4-methoxyphenyl)-3-phenylpropanoic acid (cas 114327-14-9). Pls Click Website Link as below: cas 114327-14-9 suppliers

Prev:Mutagenic activity of methyl- and fluoro-substituted derivatives of polycyclic aromatic hydrocarbons in a human hepatoma (HepG2) cell-mediated assay
Next:Dual demeanour of norcantharidin derived dicarboxamides in acidic media: An insight)