Reductive cyclization of halo-ketones to form 3-hydroxy-2-oxindoles via palladium catalyzed hydrogenation: a hydrogen-mediated Grignard addition

Add time:09/04/2019    Source:sciencedirect.com

The reductive cyclization of N-oxoacyl ortho-bromoanilides to form 3-hydroxy-2-oxindoles under the conditions of palladium catalyzed hydrogenation is described. This work may be viewed as a prelude to intermolecular hydrogen-mediated Grignard-type reductive couplings of organic halides with carbonyl compounds.

We also recommend Trading Suppliers and Manufacturers of 2-Amino-3-hydroxy-4-bromopyridine (cas 114335-54-5). Pls Click Website Link as below: cas 114335-54-5 suppliers

Prev:Comparison of effects of formoterol and BRL 37344 on isolated term-pregnant rat myometrial strips in vitro
Next:Enantiomeric enrichment of α-amino acid derivatives: recrystallization of N-Fmoc α-amino acid tert-butyl esters)