Facile synthesis of 3,4-dihydropyrimidin-2(1H)-ones and -thiones and indeno[1,2-d]pyrimidines catalyzed by p-DODECYLBENZENESULFONIC ACID (cas 121-65-3)

Add time:09/07/2019    Source:sciencedirect.com

A facile method for synthesizing 3,4-dihydropyrimidin-2(1H)-ones and -thiones in the Biginelli reaction by condensation reaction of aldehydes, β-ketoesters and urea or thiourea with p-dodecylbenzenesulfonic acid as a recyclable catalyst under solvent-free conditions at 80 °C is described. A series of indeno[1,2-d]pyrimidines was also synthesized under the same conditions by a Biginelli-like reaction of 2H-indene-1,3-dione with urea or thiourea and an aromatic aldehyde. All the products in both reactions were obtained in good to excellent yield by this simple, efficient procedure. The structures of all the synthesized compounds were established from advanced spectroscopic data.

We also recommend Trading Suppliers and Manufacturers of DODECYLBENZENESULFONIC ACID (cas 121-65-3). Pls Click Website Link as below: cas 121-65-3 suppliers

Prev:P-DODECYLBENZENESULFONIC ACID (cas 121-65-3) (DBSA), a Brønsted acid-surfactant catalyst for Biginelli reaction in water and under solvent free conditions
Next:Structure–property relationship of DODECYLBENZENESULFONIC ACID (cas 121-65-3) doped polypyrrole)