Transformation of N,N-Dimethylaniline (cas 121-69-7)-N-oxides into N-methylindolines by a tandem Polonovski–Mannich reaction
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Add time:09/26/2019 Source:sciencedirect.com
We report here a sequence of reactions for the synthesis of diversely substituted N-methylindolines from the corresponding N,N-dimethylaniline-N-oxides through a Polonovski–Mannich cyclization. Indolines are obtained in 47–61% yield from the corresponding aniline-N-oxides in one laboratory operation.
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