Identification of the major urinary and fecal metabolites of 3,5-Dinitrobenzamide (cas 121-81-3) in chickens and rats

Add time:09/09/2019    Source:sciencedirect.com

Colostomized chickens given oral doses of 3,5-Dinitrobenzamide (cas 121-81-3) (nitromide) cleared nitromide predominantly through the urine (58% of dose) and feces (21% of dose). Rats cleared 52% of nitromide via urinary excretion and 44% via feces. Major urinary metabolites for both chickens and rats include: 3-amino-5-nitrobenzamide, 3-acetamido-5-nitrobenzamide, 3-acetamide-5-aminobenzamide, and 3,5-diacetamidobenzamide. The major fecal metabolite in chickens was 3-acetamido-5-nitrobenzamide (67% of fecal 14C) and 3-acetamido-5-aminobenzamide in rats (∼50%).

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