Polymer-assisted solution-phase parallel synthesis of dipeptide p-nitroanilides and dipeptide diphenyl phosphonates
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Add time:09/06/2019 Source:sciencedirect.com
This letter describes the parallel synthesis of dipeptide p-nitroanilides (1) and dipeptide diphenyl phosphonates (2), compounds that can be used as substrates and irreversible inhibitors for the rapid profiling of dipeptidyl peptidases. A polymer-assisted solution-phase synthesis was used for a rapid and clean coupling between easily available building blocks.
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