Research ArticlesGLC determination of 7-trifluoromethyl-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4-(3H,5H)-dione in Plasma

Add time:09/24/2019    Source:sciencedirect.com

A GLC assay method is described for the determination of 7-trifluoromethyl-1-methyl-5-phenyl-1H-1,5-benzodiaze-pine-2,4-(3H,5H)-dione in the plasma or serum of dogs, rabbits, or humans. After extraction with hexane from acidified plasma or serum, the compound is analyzed by GLC using a flame-ionization detector. Quantitation is accomplished using a standard curve, which was found to be linear over the 0.002-3.5-mcg. range. The analysis is sensitive to amounts of the drug above 0.1 mcg./ml. Recovery of the title compound added to human plasma averaged 98.7%, with a variation of approximately 7.1%(RSD). Plasma data are presented to demonstrate the utility of the method.

We also recommend Trading Suppliers and Manufacturers of 5-PHENYL-2,4(1H,3H)-PYRIMIDINEDIONE (cas 15761-83-8). Pls Click Website Link as below: cas 15761-83-8 suppliers

Prev:Original articleSynthesis of novel 6-phenyl-2,4-disubstituted pyrimidine-5-carbonitriles as potential antimicrobial agents
Next:Preparation of bromo[1-14C]acetyl-coenzyme A as an affinity label for acetyl-coenzyme A binding sites☆)