Review articleThe long journey of salicylates in ulcerative colitis: The past and the future

Add time:09/06/2019    Source:sciencedirect.com

The advent of salicylates in the treatment of ulcerative colitis started in 1938 with the discovery of Salazopyrin by Nanna Svartz. This drug offered for the first time a therapeutic chance to patients with ulcerative colitis. In this paper we describe the fascinating history of Salazopyrin and salicylates from the first serendipitous observations to the last randomized clinical trials. Attention was paid to the pharmacokinetics and the mechanism of action of 5-aminosalicylates and, in particular, to the issue of the mucosal concentrations of 5-aminosalicylates and its therapeutic efficacy. Moreover a look at the new oral mesalazine formulations that allow the homogenous distribution of 5-aminosalicylate through all the large bowel was taken. Lastly, the possible use of mesalazine in the prevention of colorectal cancer was reviewed.

We also recommend Trading Suppliers and Manufacturers of disodium salicylate (cas 13639-21-9). Pls Click Website Link as below: cas 13639-21-9 suppliers

Prev:Salicylate-spectrophotometric determination of inorganic monochloramine
Next:The use of eidronate disodium in the prevention of heterotopic ossification in burn patients)