Original articleSelective cytotoxic and genotoxic activities of 5-(2-bromo-5-methoxybenzylidene)-thiazolidine-2,4-dione against NCI-H292 human lung carcinoma cells
-
Add time:09/06/2019 Source:sciencedirect.com
BackgroundThiazolidine-2,4-dione ring system is used as a pharmacophore to build various heterocyclic compounds aimed to interact with biological targets. In the present study, benzylidene-2,4-thiazolidinedione derivatives (compounds 2–5) were synthesized and screened against cancer cell lines and the genotoxicity and cytotoxicity of the most active compound (5) was investigated on normal and lung cancer cell line.
We also recommend Trading Suppliers and Manufacturers of 5-(2-METHOXYBENZYLIDENE)-2,2-DIMETHYL-1,3-DIOXANE-4,6-DIONE (cas 15795-56-9). Pls Click Website Link as below: cas 15795-56-9 suppliers
Prev:Original articleSynthesis, spectral characterization, molecular docking studies, biological activity of (E)-2-((E)-3-(3,4,5-trimethoxyphenyl)allylidene) and (E)-N-phenyl 2-((E)-3-(3,4,5-trimethoxyphenyl)allylidene)hydrazinecarbothioamides and their Cu(II) complexes
Next:Novel multitarget 5-arylidenehydantoins with arylpiperazinealkyl fragment: Pharmacological evaluation and investigation of cytotoxicity and metabolic stability) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Synthesis, spectral characterization and crystal structures of benzyltin complexes with (E)-4-chloro-N′-(2-hydroxy-4-methoxybenzylidene)benzohydrazide09/25/2019
- Manganese(III) complexes derived from 1-(2-hydroxybenzamido)-2-((2-hydroxy-3-methoxybenzylidene)amino)ethane: Synthesis, structure and magnetic properties09/24/2019
- Structure and spectroscopy of diorganotin(IV) complexes derived from N′-(2-hydroxy-3-methoxybenzylidene)benzohydrazide09/10/2019
- Laboratory noteDrugs for stroke: Action of nitrone (Z)-N-(2-bromo-5-hydroxy-4-methoxybenzylidene)-2-methylpropan-2-amine oxide on rat cortical neurons in culture subjected to oxygen–glucose-deprivation09/09/2019
- 1-(2-Methoxybenzylidene)-4-phenylthiosemicarbazide as OFF–ON fluorescent chemodosimeter for detection of Cu2+ in acetonitrile–water binary solvents09/08/2019
- Novel multitarget 5-arylidenehydantoins with arylpiperazinealkyl fragment: Pharmacological evaluation and investigation of cytotoxicity and metabolic stability09/07/2019
