Precursor directed biosynthesis of novel 6-deoxyerythronolide B (cas 15797-36-1) analogs containing non-natural oxygen substituents and reactive functionalities
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Add time:09/09/2019 Source:sciencedirect.com
Feeding of synthetic precursors to a blocked mutant of 6-deoxyerythronolide B (cas 15797-36-1) synthase (DEBS) [1] led to production of novel 6-deoxyerythronolide B analogs in vivo containing additional non-natural oxygen substituents as well as additional reactive groups.
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