Synthesis of 6-deoxyerythronolide B (cas 15797-36-1). Implementation of a general strategy for the synthesis of macrolide antibiotics
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Add time:09/26/2019 Source:sciencedirect.com
The synthesis of 6-deoxyerythronolide B (1) has been completed using the β-ketoimide dipropionyl building block 2 in the synthesis of the C1C7 and C8C15 subunits. A convergent double stereodifferentiating Mukaiyama aldol coupling reaction, a biomimetic deoxygenation, and a high-yield macrocyclization were employed in an 18-step synthesis of this natural product.
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