Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors
-
Add time:09/10/2019 Source:sciencedirect.com
5-Lipoxygenase (5-LOX) is important enzyme in the biosynthesis of leukotrienes, and is a potential target in the treatment of asthma and allergy. We designed and synthesized a series of benzoxazoles and benzothiazoles as 5-LOX inhibitors. Fourteen compounds prepared showed the inhibition of LTC4 formation with IC50 value of 0.12–23.88 μM. Also two compounds 2d and 2g showed improved airway hypersensitiveness.
We also recommend Trading Suppliers and Manufacturers of 2-Methylthio Benzoxazole (cas 13673-62-6). Pls Click Website Link as below: cas 13673-62-6 suppliers
Prev:Structure–activity relations of 2-(methylthio)benzimidazole by FTIR, FT-Raman, NMR, DFT and conceptual DFT methods
Next:Benzoxazole and benzothiazole amides as novel pharmacokinetic enhancers of HIV protease inhibitors) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Benzoxazole and benzothiazole amides as novel pharmacokinetic enhancers of HIV protease inhibitors09/24/2019
- Structure–activity relations of 2-(methylthio)benzimidazole by FTIR, FT-Raman, NMR, DFT and conceptual DFT methods09/09/2019
- 2-Amino-7-substituted benzoxazole analogs as potent RSK2 inhibitors09/08/2019
- Original articleSynthesis, antimicrobial and cytotoxic activities of pyrimidinyl benzoxazole, benzothiazole and benzimidazole09/07/2019
- Electrochemistry and electrogenerated chemiluminescence of benzoxazole derivatives in nonaqueous media09/06/2019
