Quinidine thiourea-catalyzed enantioselective synthesis of β-nitrophosphonates: beneficial effects of molecular sieves
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Add time:09/10/2019 Source:sciencedirect.com
An efficient method for enantioselective synthesis of β-nitrophosphonates via the Michael addition of diphenyl phosphite to nitroalkenes using the readily available quinidine thiourea organocatalyst has been developed. The desired β-nitrophosphonates were obtained in good ee values. Molecular sieves were found to be crucial for achieving high reproducible yields in this reaction.
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