CuCl2 induced reactions of 6-ethynyl- and 6-cyano-5-aryl-2,2′-bipyridines with various N- and O-nucleophiles in comparison with the reactions of relative 1,2,4-triazines
-
Add time:09/08/2019 Source:sciencedirect.com
Meanwhile 5-aryl-6-cyano-2,2′-bipyridines are very stable towards various nucleophiles, addition copper(II) chloride to the reactional mixture facilitates nucleophilic addition to the cyano group dramatically. The cyanobipyridines react easily with water, methanol, ethanolamine in the presence of CuCl2 yielding well-crystallized complexes containing carboxylates, carboximidates or carboxamidines as ligands. 5-Cyano-1,2,4-triazines are more active in the reactions due to higher electron-withdrawing properties of this heterocycle. Due to the same reason acetylene moiety of 5-ethynyl-3-pyridyl-1,2,4-triazine adds water quite easily but in the presence of copper chloride as well.
We also recommend Trading Suppliers and Manufacturers of METHYL 1,2,4-TRIAZINE-3-CARBOXYLATE (cas 16721-40-7). Pls Click Website Link as below: cas 16721-40-7 suppliers
Prev:An unexpected synthesis of 3,5-diaryl-1,2,4-thiadiazoles from thiobenzamides and methyl bromocyanoacetate
Next:A ready one-pot preparation for pyrrolo[2,1-f]-[1,2,4]triazine and pyrazolo[5,1-c]pyrimido[4,5-e]-[1,2,4]triazine derivatives) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Metalated azolo[1,2,4]triazines. II. Generation, C(4)-substituent dependent stability and electrophile trapping of 7-lithiopyrazolo[5,1-c][1,2,4]triazines09/26/2019
- Synthesis of 2-perfluoroalkyl-1,4-dihydropyrazolo[1,5-a][1,3,5]triazines via rearrangements of (1-perfluoroacetyl-1,4-dihydropyrazolo[5,1-c][1,2,4]triazin-4-yl)lithiums09/25/2019
- Synthesis of isoquinolines by cycloaddition of arynes to 1,2,4-triazines09/24/2019
- Diels-alder reactions of 1,2,4-triazines with cyclic vinyl ethers09/10/2019
- A ready one-pot preparation for pyrrolo[2,1-f]-[1,2,4]triazine and pyrazolo[5,1-c]pyrimido[4,5-e]-[1,2,4]triazine derivatives09/09/2019
- An unexpected synthesis of 3,5-diaryl-1,2,4-thiadiazoles from thiobenzamides and methyl bromocyanoacetate09/07/2019
- Synthesis of carbon-11-labeled 4-(phenylamino)-pyrrolo[2,1-f][1,2,4]triazine derivatives as new potential PET tracers for imaging of p38α mitogen-activated protein kinase09/06/2019
-
Health and Chemical more >
-
Related Products
- Methyl 1-Benzyl-5-oxopyrrolidine-3-carboxylate
- Methyl (((methoxymethylphosphinothioyl)thio)acetyl)methylcarbamate
- Methyl (+)-(3R)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesulfonylamino)pyrimidin-5-yl]-3-hydroxy-5-oxo-(6E)-heptenoate
- Methyl (2-amino-5-methyl-1,3-thiazol-4-yl)acetate
- Methyl (2-chloromethyl)oxazole-4-carboxylate
- Methyl (2E)-3-(4-methylphenyl)propenoate
- Methyl (2E)-3-cyclohexylprop-2-enoate
- Methyl (2R)-2-[(tert-butoxycarbonyl)amino]-3-iodopropanoate
- Methyl (2R)-2-[4-(2,4-dichlorophenoxy)phenoxy]propanoate
- Methyl (2R)-2-amino-2-cyclohexylethanoate hydrochloride