Catalytic asymmetric synthesis of β-hydroxy-α-amino acid esters by direct aldol reaction of glycinate Schiff bases

Add time:09/09/2019    Source:sciencedirect.com

A catalytic asymmetric synthesis of β-hydroxy-α-amino acid esters was developed using the direct aldol reaction of glycinate Schiff bases with aldehydes. The reaction was catalyzed by heterobimetallic asymmetric complexes without preformation of enol silyl ethers from glycinate Schiff bases. anti-β-Hydroxy-α-amino acid esters were obtained as the major diastereomer in most cases, and moderate enantiomeric excess (up to 76% ee) was achieved for the first time for this type of reaction. Various substrates were also examined to investigate the effects of the protective groups for the amine or for the carboxylic acid moiety in glycine.

We also recommend Trading Suppliers and Manufacturers of Aluminium glycinate (cas 13682-92-3). Pls Click Website Link as below: cas 13682-92-3 suppliers

Prev:Research reportAccumulation of aluminum by primary cultured astrocytes from aluminum amino acid complex and its apoptotic effect
Next:FT-IR vibrational spectrum and DFT:B3LYP/6-31G and B3LYP/6-311G structure and vibrational analysis of glycinate–guanidoacetate nickel (II) complex: [Ni(Gly)(Gaa)])