Response of two strains of L5178Y cells to cis-dichlorobis-(cyclopentylamine)platinum(II). I. cross-sensitivity to cis-PAD and UV light

Add time:09/10/2019    Source:sciencedirect.com

The response to cis-dichlorobis(cyclopentylamine)platinum(II) (cis-PAD) an antitumour platinum complex, was studied in two strains of murine lymphoma L5178Y cross-sensitive to X-rays and UV light. Dose-survival relationship, DNA synthesis, formation of chromatid aberrations, progression through the cell cycle, and growth and viability changes after 1 h cis-PAD treatment at 37°C were examined and compared with the effects of X-rays and UV light.In both strains, cis-PAD caused immediate inhibition of progression through the cell cycle, reduced rate of DNA synthesis, delayed appearance of chromatid aberrations, and delayed death; however, there is a marked difference in sensitivity to cis-PAD between L5178Y-S strain Do approx. 5.8 μg/ml and L5178Y-R strain (D0) approx. 2.5 μg/ml. In both strains a close resemblance was found between dose-survival relationships after cis-PAD and UV light treatment, respectively.

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