Trichloroisocyanuric acid-mediated synthesis of 1,5-fused 1,2,4-triazoles from N-heteroaryl benzamidines via intramolecular oxidative N–N bond formation

Add time:09/07/2019    Source:sciencedirect.com

A convenient synthesis of 1,5-fused 1,2,4-triazoles from readily available N-heteroaryl benzamidines is reported. The reaction is efficiently promoted by trichloroisocyanuric acid to afford the desired products, mostly in high yields and in relatively short time, through direct metal-free oxidative N–N bond formation. The mild nature of the synthesis and short reaction time are notable advantages of the developed protocol. This protocol is effective toward various substrates having different functionalities.

We also recommend Trading Suppliers and Manufacturers of 2-CHLORO-BENZAMIDINE (cas 18637-02-0). Pls Click Website Link as below: cas 18637-02-0 suppliers

Prev:Response of two strains of L5178Y cells to cis-dichlorobis-(cyclopentylamine)platinum(II). I. cross-sensitivity to cis-PAD and UV light
Next:Binding of benzamidine and protons to trypsin as measured by difference spectra☆)