Welcome to LookChem.com Sign In | Join Free
Home > Chemical Encyclopedia > Science List > Details
  • Efficacy of a combination of nisin and p-Anisaldehyde (cas 123-11-5) against Listeria monocytogenes

  • Add time:09/08/2019    Source:sciencedirect.com

    Nisin is used as a food-safe antimicrobial agent and has been widely applied to daily food products to prevent bacterial growth. However, the practical application of nisin is limited. Although nisin inhibits the growth of Listeria monocytogenes, exposure to this agent is also a risk factor for the development of nisin resistance. p-Anisaldehyde (cas 123-11-5) (AS) is used in the pharmaceutical industry to manufacture antimicrobial drugs, but few studies have been reported describing the antibacterial activity of AS in the food field. Combining nisin with AS may enhance antimicrobial activity. The synergy observed in vitro was confirmed by checkerboard microdilution method, with the fractional inhibitory concentration index (FICI) values ranging from 0.125 to 0.281. When AS was combined with nisin, a strong synergistic effect was observed using the time-kill and agar-diffusion assays. SEM and LIVE/DEAD BacLight experiment results also suggest that the bactericidal mechanism of the drug combination involves cell wall lysis and membrane damage. We can use this synergy to achieve a stable antimicrobial effect to overcome antimicrobial drug resistance.

    We also recommend Trading Suppliers and Manufacturers of p-Anisaldehyde (cas 123-11-5). Pls Click Website Link as below: cas 123-11-5 suppliers

    Prev:Synergistic antimicrobial effects of nisin and p-Anisaldehyde (cas 123-11-5) on Staphylococcus aureus in pasteurized milk
    Next:Vibrational spectroscopy investigation using ab initio and density functional theory on p-Anisaldehyde (cas 123-11-5))

  • Back】【Close 】【Print】【Add to favorite
Periodic Table
    Related Products