Comparative solution and structural studies of half-sandwich rhodium and ruthenium complexes bearing curcumin and Acetylacetone (cas 123-54-6)

Add time:10/01/2019    Source:sciencedirect.com

Half-sandwich organometallic complexes of curcumin are extensively investigated as anticancer compounds. Speciation studies were performed to explore the solution stability of curcumin complexes formed with [Rh(η5-C5Me5)(H2O)3]2+. Acetylacetone (Hacac), as the simplest β-diketone ligand bearing (O,O) donor set, was involved for comparison and its Ru(η6‑p‑cymene), Ru(η6‑toluene) complexes were also studied. 1H NMR, UV–visible and pH-potentiometric titrations revealed a clear trend of stability constants of the acac complexes: Ru(η6‑p‑cymene) > Ru(η6‑toluene) > Rh(η5-C5Me5). Despite this order, the highest extent of complex formation is seen for the Rh(η5-C5Me5) complexes at pH 7.4. Formation constant of [Rh(η5-C5Me5)(H2curcumin)(H2O)]+ reveals similar solution stability to that of the acac complex. Additionally, structures of two complexes were determined by X-ray crystallography. The in vitro cytotoxicity of curcumin was not improved by the complexation with these organometallic cations.

We also recommend Trading Suppliers and Manufacturers of Acetylacetone (cas 123-54-6). Pls Click Website Link as below: cas 123-54-6 suppliers

Prev:Fate and implication of Acetylacetone (cas 123-54-6) in photochemical processes for water treatment
Next:Reactivity of the HoPc2I in the Acetylacetone (cas 123-54-6)–water system)