Synthesis, antimicrobial activity and quantum chemical investigation of novel Succinimide (cas 123-56-8) derivatives
-
Add time:09/24/2019 Source:sciencedirect.com
In the present study, twelve new 1-aryl-3-ethyl-3-methylpyrrolidine-2,5-diones were synthesized and their structures were characterized by FT-IR, 1H NMR, 13C NMR spectroscopy and elemental analysis. In the final step of synthetic rout, condensation between corresponding succinic acid and substituted anilines has been improved using the microwave irradiation. Significantly higher yields compared to conventional condensation have been observed. The preliminary biological results indicated that some of the synthesized compounds showed promising in vitro antifungal activities towards several test fungi. 1-(4-Bromophenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione (8) exhibited significant in vitro inhibitory activities against broad spectra of fungus, and on the basis of obtained data, the investigated bromo derivative has to be observed as novel potential fungicide. The density functional theory (DFT) calculations have been performed in order to study the structure-activity relationship (SAR) of the investigated molecules. In order to prediction of the chemical activity of the molecule, the molecular electrostatic potential (MEP) map was analyzed for the optimized geometry of 1-phenyl-3-ethyl-3-methylpyrrolidine-2,5-dione (4) and 1-(4-bromophenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione (8).
We also recommend Trading Suppliers and Manufacturers of Succinimide (cas 123-56-8). Pls Click Website Link as below: cas 123-56-8 suppliers
Prev:Research ArticlePharmaceutical BiotechnologyCharacterization of Ring-Opening Reaction of Succinimide (cas 123-56-8) Linkers in ADCs
Next:Research paperSynthesis and biological evaluation of novel benzylidene-Succinimide (cas 123-56-8) derivatives as noncytotoxic antiangiogenic inhibitors with anticolorectal cancer activity in vivo) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Succinimide (cas 123-56-8)-KI: An efficient binary catalyst system for mild, solvent-free cycloaddition of CO2 to epoxides09/28/2019
- Conformational, spectroscopic (FT-IR, FT-Raman, and UV-Vis), and molecular docking studies of N-(2-hydroxyethyl) Succinimide (cas 123-56-8)10/01/2019
- Synthesis of quaternary Succinimide (cas 123-56-8)s promoted by Ferric Nitrate09/27/2019
- Characterization of Succinimide (cas 123-56-8) stability during trypsin digestion for LC-MS analysis09/26/2019
- Research paperSynthesis and biological evaluation of novel benzylidene-Succinimide (cas 123-56-8) derivatives as noncytotoxic antiangiogenic inhibitors with anticolorectal cancer activity in vivo09/25/2019
- Research ArticlePharmaceutical BiotechnologyCharacterization of Ring-Opening Reaction of Succinimide (cas 123-56-8) Linkers in ADCs09/10/2019
- Characterization and quantification of Succinimide (cas 123-56-8) using peptide mapping under low-pH conditions and hydrophobic interaction chromatography09/09/2019
- General CommentaryAn Automated and Qualified Platform Method for Site-Specific Succinimide (cas 123-56-8) and Deamidation Quantitation Using Low-pH Peptide Mapping09/08/2019