Synthesis, characterization and radiolabelling of 2-{6-(4-bromophenoxy)hexyl}oxirane-2-carboxylic acid

Add time:07/15/2019    Source:sciencedirect.com

A method is described for the synthesis, purification and radiolabelling of 2-{6-(4-bromophenoxy)hexyl}oxirane-2-carboxylic acid. For the synthesis of this new agent, 6-(4-bromophenoxy)hexylbromide (1), synthesized by the treatment of 4-bromophenol with 1,6-dibromohexane under basic conditions, was converted to diethyl 6-(4-bromophenoxy)hexylmalonate (2), which, on alkaline hydrolysis, yielded ethyl 6-(4-bromophenoxy)hexylmalonate (3). Ethyl 8-(4-bromophenoxy)-2-methyleneoctanoate (4), prepared from the monoester (3), was oxidized with m-chloroperbenzoic acid to yield ethyl 2-{6-(4-bromophenoxy)hexyl}oxirane-2-carboxylate (5). The method of radiolabelling, based on the Cu(I)Cl-assisted nucleophilic exchange reaction, resulted in regioselective radiobromination with a 45% radiochemical yield.

We also recommend Trading Suppliers and Manufacturers of 2-(4-bromophenoxy)-5-nitropyridine (cas 219865-88-0). Pls Click Website Link as below: cas 219865-88-0 suppliers

Prev:Synthesis, single crystal analysis and DFT based computational studies of 2,4-diamino-5-(4-chlorophenyl)-6-ethylpyrim idin-1-ium 3,4,5-trihydroxybenzoate -methanol (DETM)
Next:Experimental and DFT studies for the kinetics and mechanism of the pyrolysis of 2-(4-substituted-phenoxy)tetrahydro-2H-pyranes in the gas-phase)