Preparation of in situ hydrogels loaded with Azelaic acid (cas 123-99-9) nanocrystals and their dermal application performance study
-
Add time:09/09/2019 Source:sciencedirect.com
Azelaic acid (cas 123-99-9) (AZA) is a dicarboxylic acid that is topically used in the treatment of acne and rosacea since it possesses antibacterial and keratolytic activity. The primary objective of this study was to develop an AZA nanocrystal suspension. It is expected that improved solubility and dissolution rate will result in advanced biopharmaceutical properties, primarily the dermal bioavailability. Furthermore, a topical nanocrystal AZA-loaded hydrogels composed of Pluronic® F127 and hyaluronic acid mixture that are able to deliver AZA into the stratum corneum and deeper skin layers were considered. This study was conducted in order to: 1) determine the effect of non-ionic Polysorbate 60 on the stabilization and particle size of the AZA nanocrystals, as well as the effect of Pluronic® F127, used as an in situ gelation agent, and hyaluronic acid on the viscoelastic properties and the drug release of composed hydrogels, 2) determine the relationship between the rheological properties of the gels and the penetration of AZA into the stratum corneum. The composed hydrogels revealed pseudoplastic flow behaviour. The increase in Pluronic® F127 concentration induced a domination of elastic over viscous behaviour of the gels. The gel containing 15% of Pluronic® F127, 1% of hyaluronic acid and lyophilised 10% nanocrystal AZA suspension was considered to be an optimal formulation, since it possessed the rheological and drug delivery properties desirable for an in situ gelling platform for dermal application.
We also recommend Trading Suppliers and Manufacturers of Azelaic acid (cas 123-99-9). Pls Click Website Link as below: cas 123-99-9 suppliers
Prev:Preparation of antibacterial TiO2 particles by hybridization with Azelaic acid (cas 123-99-9) for applications in cosmetics
Next:New effective Azelaic acid (cas 123-99-9) liposomal gel formulation of enhanced pharmaceutical bioavailability) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Effect of 1,4-cyclohexanediol on percutaneous absorption and penetration of Azelaic acid (cas 123-99-9)10/01/2019
- Olfactory receptor Olfr544 responding to Azelaic acid (cas 123-99-9) regulates glucagon secretion in α-cells of mouse pancreatic islets09/27/2019
- Molecular determinants of the olfactory receptor Olfr544 activation by Azelaic acid (cas 123-99-9)09/26/2019
- Untargeted metabolomics analysis reveals dynamic changes in Azelaic acid (cas 123-99-9)- and salicylic acid derivatives in LPS-treated Nicotiana tabacum cells09/25/2019
- Nanostructured gel for topical delivery of Azelaic acid (cas 123-99-9): Designing, characterization, and in-vitro evaluation09/24/2019
- New effective Azelaic acid (cas 123-99-9) liposomal gel formulation of enhanced pharmaceutical bioavailability09/10/2019
- Preparation of antibacterial TiO2 particles by hybridization with Azelaic acid (cas 123-99-9) for applications in cosmetics09/08/2019
-
Health and Chemical more >