Glucosylated liposomes as drug delivery systems of USNIC ACID (cas 125-46-2) to address bacterial infections

Add time:09/09/2019    Source:sciencedirect.com

Because of the increased incidence of infections caused by resistant pathogens, due to the intensive use of antibiotics, there is an urgent need to develop new therapeutic strategies against bacteria, possibly based on non conventional drugs. (+)-USNIC ACID (cas 125-46-2) is a natural compound that exerts a potent antibacterial activity, however its clinical application is hampered by its scarce solubility in water. Usnic acid was included, by both passive and active loading techniques, in liposomes containing structurally related glucosylated amphiphiles. Liposome formulations were characterized from the physicochemical point of view and their activity against biofilm associated Staphylococcus epidermidis was also evaluated. The inclusion of usnic acid in glucosylated cationic liposomes promotes its penetration in biofilm matrix with a consequent increase of its antimicrobial activity. The effect of both cationic charge and sugar residue seems to be synergistic.

We also recommend Trading Suppliers and Manufacturers of USNIC ACID (cas 125-46-2). Pls Click Website Link as below: cas 125-46-2 suppliers

Prev:Genotoxicity of (+)- and (−)-USNIC ACID (cas 125-46-2) in mice
Next:Full length articleEffects of (+)-USNIC ACID (cas 125-46-2) and (+)-USNIC ACID (cas 125-46-2)-liposome on Toxoplasma gondii)