Naloxone blocks the analgesic action of levorphanol but not of dextrorphan in the leopard frog

Add time:09/24/2019    Source:sciencedirect.com

Intraspinal injection of levorphanol (3 μg) at the lumbar area of the leopard frog,Rana pipiens, induced analgesia which was completely blocked by co-injection of naloxone (3 μg), whereas dextrorphan (3 μg) induced analgesia which was unaffected by naloxone. Subcutaneous levorphanol (20 or 80 mg/kg) induced a dose-dependent analgesia which was blocked by concurrent naloxone (2 mg/kg), while only the higher dose of dextrorphan (80 mg/kg) induced analgesia which was unaffected by concurrent naloxone at 8 or 80 mg/kg. These data are the first to indicate naloxone-insensitive, dextrorphan-induced analgesia.

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