Chemo-/regio-selective synthesis of 2-aryl-3-acetyl-2,4-dihydro-1H-5H-1,5-benzodiazepines using Lewis acid, CeCl3·7H2O

Add time:09/08/2019    Source:sciencedirect.com

A unique and efficient method has been developed for the one-pot synthesis of 2-aryl-3-acetyl-2,4-dihydro-1H-5H-1,5-benzodiazepines (4aa–4fa) in good yields using o-phenylenediamine, aromatic aldehyde and 3-butyn-2-one in the presence of a catalytic amount of CeCl3·7H2O in ethanol at ambient temperature. An exclusive chemo-/regio-selective formation of substituted isomers of 2-aryl-3-acetyl-2,4-dihydro-1H-5H-1,5-benzodiazepines was achieved from the different reaction process, by exploiting the strategy based on the variation of electrophilicity of the two electrophilic centers of aromatic aldehyde, 3-butyn-2-one and nucleophilic profiles of substituted o-phenylenediamines. This process offers an easy and efficient synthesis of 2-aryl-3-acetyl-2,4-dihydro-1H-5H-1,5-benzodiazepines in high yields.

We also recommend Trading Suppliers and Manufacturers of 4-METHYL-2-THIAZOLECARBOXALDEHYDE 97 (cas 13750-68-0). Pls Click Website Link as below: cas 13750-68-0 suppliers

Prev:Cd(II), Hg(II) and Pt(II) complexes of 1-ethyl-3-(4-methylthiazol-2-yl)thiourea: Synthesis, X-ray crystal structure, DFT studies, antimicrobial and antioxidant applications
Next:DFT, FT-IR and FT-Raman investigations of 1-Methyl-2-imidazolecarboxaldehyde (cas 13750-81-7))