Nitidine chloride (cas 13063-04-2) inhibits renal cancer cell metastasis via suppressing AKT signaling pathway
-
Add time:09/27/2019 Source:sciencedirect.com
Nitidine chloride (cas 13063-04-2) (NC) has been shown to have anti-cancer effects on various tumors. However, whether NC could exert anti-metastasis activity in renal cancer cells and the underlying mechanisms have not been elucidated. In this work, our data demonstrated the anti-metastasis effects of NC on renal cancer cells in vitro. With scratch assay and transwell assays, we found that NC potently suppressed the migration and invasion of 786-O and A498 cells. Mechanistically, we presented that NC significantly decreased phosphorylation of AKT, accompanied by down-regulation of MMP-2 and MMP-9. Furthermore, a specific AKT inhibitor, LY294002, could enhance the anti-metastasis effects of NC, which indicated that NC suppressed metastasis of renal cancer cells partly via inhibition of AKT activity. Taken together, our results imply that NC can be developed as a potential anti-metastasis agent to renal cancer.
We also recommend Trading Suppliers and Manufacturers of Nitidine chloride (cas 13063-04-2). Pls Click Website Link as below: cas 13063-04-2 suppliers
Prev:Original articleDetermination and Pharmacokinetic Study of Nitidine chloride (cas 13063-04-2) in Rat Plasma after Intragastrical Administration by LC-ESI-MS/MS Method
Next:Nitidine chloride (cas 13063-04-2) inhibits breast cancer cells migration and invasion by suppressing c-Src/FAK associated signaling pathway) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Nitidine chloride (cas 13063-04-2) induces apoptosis and inhibits tumor cell proliferation via suppressing ERK signaling pathway in renal cancer09/29/2019
- Nitidine chloride (cas 13063-04-2) inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kappaB pathway in RAW 264.7 cells09/28/2019
- Nitidine chloride (cas 13063-04-2) inhibits breast cancer cells migration and invasion by suppressing c-Src/FAK associated signaling pathway10/01/2019
- Original articleDetermination and Pharmacokinetic Study of Nitidine chloride (cas 13063-04-2) in Rat Plasma after Intragastrical Administration by LC-ESI-MS/MS Method09/26/2019
- The effects of Nitidine chloride (cas 13063-04-2) and camptothecin on the growth of Babesia and Theileria parasites09/25/2019
- Supramolecular formulation of Nitidine chloride (cas 13063-04-2) can alleviate its hepatotoxicity and improve its anticancer activity09/24/2019
- Nitidine chloride (cas 13063-04-2) exerts anti-inflammatory action by targeting Topoisomerase I and enhancing IL-10 production09/10/2019
- Original articlepDok2, caspase 3 dependent glioma cell growth arrest by Nitidine chloride (cas 13063-04-2)09/09/2019
- Original ArticleNitidine chloride (cas 13063-04-2) Inhibits SIN1 Expression in Osteosarcoma Cells09/08/2019
-
Health and Chemical more >
-
Related Products