Control of site selectivity in trifluoromethylation of alkenes bearing a pendant indolyl group: Synthesis of CF3-containing tetrahydrocarbazoles

Add time:09/09/2019    Source:sciencedirect.com

We present a tetrahydrocarbozole-forming carbo-trifluoromethylation of indoles bearing an alkenyl group at the C3 position. The reaction proceeded selectively with the combination of TsOH·H2O as a catalyst and CH2Cl2 as a solvent. The site-selectivity could be altered by changing the reaction solvent; the use of THF instead of CH2Cl2 increased the formation of aromatic trifluoromethylation products.

We also recommend Trading Suppliers and Manufacturers of 6-Methoxy-1,2,3,4-tetrahydrocarbazole (cas 13070-45-6). Pls Click Website Link as below: cas 13070-45-6 suppliers

Prev:Binding of methoxy-substituted N1-benzenesulfonylindole analogs at human 5-HT6 serotonin receptors
Next:Short communication1-O-Benzyl-2-O-methyl-rac-glycerol: a key intermediate for synthesis of ether glycerolipids)