Acute lethality of D- and L-ETHIONINE (cas 13073-35-3) in Swiss mice
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Add time:09/26/2019 Source:sciencedirect.com
SummaryThe acute, 7-day LD50 in Swiss mice of D-ethionine administered intraperitoneally, was determined as 185 mg/kg with 95% confidence limits of 163 and 210 mg/kg. L-ETHIONINE (cas 13073-35-3), the stereoisomer, which is more potent in inhibiting liver RNA synthesis, was not lethal at 2500 mg/kg. This acute toxicity of D-ethionine was suppressed by L-methionine and adenine. Blood accumulation in the thoracic cavity and pericardium was the probable cause of death.
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