Synthesis of 3-acetonyl- and 3-(2-oxoethyl)glutarates

Add time:09/25/2019    Source:sciencedirect.com

Several synthetic routes to 3-acetonyl- and 3-(2-oxoethyl)glutarates 1–5 have been explored. The most advantageous involves, as the key steps, the conjugate addition of an appropriately substituted vinylmagnesium bromide to an alkylidenemalonic ester, a bis-homologation of the resulting diester and, finally, the reductive ozonolysis of the carbon–carbon double bond. The synthesis can be satisfactorily conducted in good overall yield on a multigram scale.

We also recommend Trading Suppliers and Manufacturers of Dimethyl Glutarate (cas 1119-40-0). Pls Click Website Link as below: cas 1119-40-0 suppliers

Prev:Desymmetrization of dimethyl 3-substituted glutarates through enzymatic ammonolysis and aminolysis reactions
Next:Original articleSynthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidines as potential nonclassical antifolates targeting both thymidylate and purine nucleotide biosynthesis)