7-(Disubstituted thiazolyl)-3,5-dihydroxy-6-heptenoic/heptanoic acid derivatives as HMG-COa reductase inhibitors
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Add time:09/10/2019 Source:sciencedirect.com
A series of disubstituted thiazoles, functionalized with the essential 3,5-dihydroxy-6-heptenoic or heptanoic chain, were prepared and evaluated for their ability to inhibit the enzyme HMG-CoA reductase in vitro. All the synthesized compounds 46–61 showed a moderate inhibitory potency.
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