A new synthesis of 3,5-dihydroxy-7-(1-pyrrolyl)-6-HEPTENOIC ACID (cas 1119-60-4)s, a family of HMGCoA reductase inhibitors with antifungal activity
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Add time:09/24/2019 Source:sciencedirect.com
Starting from a 3,5-dihydroxyheptanoic acid derivative, a new synthesis of pyrrole statins that contain a double bond on the dihydroxyacid chain has been developed. Key steps are N-acylamino acid enamide formation through enamine trapping with aromatic acyl chlorides and subsequent münchnone cycloaddition with activated acetylenes.
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