Antitumor platinum(II) complexes of N-cyclobutyl-1R,2R-diaminocyclohexane with dicarboxylates as leaving groups
-
Add time:09/09/2019 Source:sciencedirect.com
Four platinum(II) complexes of N-cyclobutyl-1R,2R-diaminocyclohexane with different bidentate dicarboxylates (1 oxalate, 2 malonate, 3 1,1-cyclobutanedicarboxylate and 4 3-hydroxy-1,1-cyclobutanedicarboxylate) as leaving groups were synthesized and characterized by elemental analyses, IR and 1HNMR spectra together with ESI-MS spectroscopy. All complexes showed considerable cytotoxicity against the tested four human tumor cell lines including A549, HCT-116, HepG-2 and MCF-7. Especially, complex 4 showed good cytotoxicity against A549 (IC50 = 3.5 μM) and HCT-116 (IC50 = 0.9 μM) cancer cell lines. Moreover, complex 3 is the most effective agent among the tested compounds against MCF-7 cell line (IC50 = 1.1 μM). The DNA binding behavior of both complexes 3 and 4, studied by agarose gel electrophoresis, revealed that they bound to DNA in almost the same way as cisplatin.
We also recommend Trading Suppliers and Manufacturers of Cyclobutyl chloride (cas 1120-57-6). Pls Click Website Link as below: cas 1120-57-6 suppliers
Prev:Thermodynamics of METHYLENECYCLOBUTANE (cas 1120-56-5)
Next:Cyclobutyl phenyl sulfoxide and (SR)-cyclobutyl p-tolyl sulfoxide: New reagents for the spiroannelation of cyclopentanone) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Synthesis and biological evaluation of anti-1-amino-2-[18F]fluoro-cyclobutyl-1-carboxylic acid (anti-2-[18F]FACBC) in rat 9L gliosarcoma09/30/2019
- Highly stereoselective syntheses of alkenylsilanes and germanes utilizing cyclobutyl ketones09/29/2019
- Synthesis and evaluation of a new series of 1′-cyclobutyl-6-(4-piperidyloxy)spiro[benzopyran-2,4′-piperidine] derivatives as high affinity and selective histamine-3 receptor (H3R) antagonists09/28/2019
- Enantiodivergent synthesis of cyclobutyl-(Z)-α,β-dehydro-α-amino acid derivatives from (−)-cis-pinononic acid10/01/2019
- Cyanuric chloride–dimethylformamide mediated cleavage of cyclopropylcarbinols-synthesis of phenolic antioxidant and construction of a new vinylcyclopropane skeleton09/27/2019
- Cyclobutyl neighboring group effect on the stability of bicyclo-[2.2.2]octyl bridgehead carbenium ions☆09/26/2019
- Stereoselective synthesis of cyclobutyl γ-amino acids leading to branched peptides with a cyclobutane core09/25/2019
- Synthesis and evaluation of 4-alkoxy-[1′-cyclobutyl-spiro(3,4-dihydrobenzopyran-2,4′-piperidine)] analogues as histamine-3 receptor antagonists09/24/2019
- Cyclobutyl phenyl sulfoxide and (SR)-cyclobutyl p-tolyl sulfoxide: New reagents for the spiroannelation of cyclopentanone09/10/2019
