Synthesis of 4-carboxy-2-thiabicyclo [3.2.0] Heptan-6-ones via 3-carboxy-2,3-Dihydrothiophene (cas 1120-59-8)s: potential β-lactamase inhibitors
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Add time:09/28/2019 Source:sciencedirect.com
3-Carboalkoxy-2,3-dihydrothiophenes, available by Birch reduction of thiophene-3-carboxylic acid or more efficiently by deconjugation of 2,5-dihydrothiophene-3-carboxylic acid by reaction with ethyl chloroformate and triethylamine, undergo cycloaddition reactions with dichloroketene leading to 4-carboxy-7,7-dichloro-2-thiabicyclo[3.2.0]heptan-6-ones which are of interest as potential β-lactamase inhibitors.
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