A new two-step procedure for functionalized-3(2H)-pyridazinones through homolytic substitution of 3-CHLOROPYRIDAZINE (cas 1120-95-2)s.☆
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Add time:09/09/2019 Source:sciencedirect.com
The homolytic substitution of protonated 3-chloro-6-methylpyridazine 1a, followed by hydrolysis with AcOH affords 4- or 4,5-functionalized pyridazinones 3a-c. Less reactivity is found for 3-chloro-6-phenylpyridazine 1b. Hypotheses about these different behaviour patterns are proposed and discussed
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