Synthesis and biological evaluation of 3-amino-, 3-alkoxy- and 3-aryloxy-6-(hetero)arylpyridazines as potent antitumor agents
-
Add time:09/10/2019 Source:sciencedirect.com
Various 3-amino-, 3-aryloxy- and alkoxy-6-arylpyridazines have been synthesized by an electrochemical reductive cross-coupling between 3-amino-, 3-aryloxy- or 3-alkoxy-6-chloropyridazines and aryl or heteroaryl halides. In vitro antiproliferative activity of these products was evaluated against a representative panel of cancer cell lines (HuH7, CaCo-2, MDA-MB-231, HCT116, PC3, NCI-H727, HaCaT) and oncogenicity prevention of the more efficient derivatives was highlighted on human breast cancer cell line MDA-MB 468-Luc prior establishing their interaction with p44/42 and Akt-dependent signaling pathways.
We also recommend Trading Suppliers and Manufacturers of 3-CHLOROPYRIDAZINE (cas 1120-95-2). Pls Click Website Link as below: cas 1120-95-2 suppliers
Prev:A new two-step procedure for functionalized-3(2H)-pyridazinones through homolytic substitution of 3-CHLOROPYRIDAZINE (cas 1120-95-2)s.☆
Next:Efficient one-step synthesis of 3-amino-6-arylpyridazines) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- (3-Pyridazinamin-3-yl) α-aminoacids: A facilitated method of preparation of phenylalanine and proline representatives09/26/2019
- Rhodium(I) complexes with pyridazine, 4,6-dimethyl-pyrimidine, 4,6-bis(3,5-dimethylpyrazol-1-yl)pyrimidine, 3,6-bis(3,5-dimethylpyrazol-1-yl)pyridazine and 3-(3,5-dimethylpyrazol-1-yl)-6-chloropyridazine09/25/2019
- Efficient one-step synthesis of 3-amino-6-arylpyridazines09/24/2019
- A new two-step procedure for functionalized-3(2H)-pyridazinones through homolytic substitution of 3-CHLOROPYRIDAZINE (cas 1120-95-2)s.☆09/09/2019
