Design and synthesis of novel series of 5-HT6 receptor ligands having indole, a central aromatic core and 1-amino-4 methyl piperazine as a positive ionizable group

Add time:07/18/2019    Source:sciencedirect.com

The exclusive distribution of 5-HT6 receptor in the brain regions and high affinity for antipsychotic and antidepressant drugs makes 5-HT6 receptor a promising target in treatment of CNS diseases. Based on a pharmacophore model reported in the literature, we designed and synthesized a novel series of 5-HT6 receptor ligands having indole as a central aromatic core and 1-amino-4-methyl piperazine as positive ionizable group. Out of 32 compounds we have successfully identified 10 new compounds as 5-HT6 receptor antagonists. The structure–activity relationship (SAR) studies have been carried out by mapping the compounds with the 3D QSAR model.

We also recommend Trading Suppliers and Manufacturers of Piperazine, 1-ethyl-4-[(4-nitrophenyl)sulfonyl]- (cas 385403-85-0). Pls Click Website Link as below: cas 385403-85-0 suppliers

Prev:Preparation of piperazine derivatives as 5-HT7 receptor antagonists
Next:Efficient, scalable kinetic resolution of cis-4-benzyloxy-2,3-epoxybutanol)