A novel and practical method for the synthesis of dinotefuran through Michael addition of nitromethane to diethyl maleate
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Add time:07/17/2019 Source:sciencedirect.com
A novel and practical synthesis of dinotefuran 1, featuring a new access to it from known key intermediate (tetrahydrofuran-3-yl)-methanamine 5, has been achieved through Michael addition reaction of nitromethane to diethyl maleate in 6 steps with 45.5% total yield. This synthesis is scalable and hence has high potential for application to further synthetic elaboration on such new neonicotinoid insecticide dinotefuran 1.
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