α-(3-Pyridyl)malonates: preparation and synthetic applications

Add time:07/21/2019    Source:sciencedirect.com

Alkylation of aromatic rings is a major challenge in organic syntheses since more complex carbon skeletons can be constructed. The alkylation of pyridine by nucleophilic aromatic substitution of the nitro group in methyl 3-nitro-4-pyridylcarboxylate (1) with malonic ester is reported. The versatility of the α-(3-pyridyl) malonic ester product (3) is demonstrated by the formation of a number of new 3-alkylated pyridines and new fused bis-heterocycles. cis 2-Halomethyl-4-(3-pyridyl)tetrahydrofuran products were selectively prepared. Exact 1H and 13C NMR assignments of practically all products were obtained by a series of NMR experiments.

We also recommend Trading Suppliers and Manufacturers of DIETHYL-2-(TETRAHYDROFURAN-3-YL)MALONATE (cas 949885-88-5). Pls Click Website Link as below: cas 949885-88-5 suppliers

Prev:Preparation of both enantiomers of cyclopropane derivatives from the reaction of vinyl selenones with di-(−)-bornyl malonate
Next:A new strain of Acinetobacter baumannii and characterization of its ghost as a candidate vaccine)