An efficient large scale resolution of (±)-threo-methylphenidate hydrochloride (Ritalin® hydrochloride)
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Add time:07/19/2019 Source:sciencedirect.com
An efficient and large scale preparation of (2R,2′R)-(+)-threo-methylphenidate hydrochloride (3) by the resolution of (±)-threo-methylphenidate hydrochloride (1) salt with O,O′-dibenzoyl-d-(+)-tartaric acid in the presence of 4-methylmorpholine is described.
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