Drug StandardsQuantitative Analysis of Sodium Sulfacetamide Solutions in the Presence of Hydrolysis Products, Sulfanilamide and Sodium Acetate

Add time:10/01/2019    Source:sciencedirect.com

The official assay for sodium sulfacetamide, the diazotization method, does not differentiate between sulfacetamide and its hydrolytic product, sulfanilamide. A spectrophotometric method involving the formation of ferric acethydroxamate was developed for utilization in studies of the rate of hydrolytic decomposition of 30 buffered and unbuffered solutions of sodium sulfacetamide at several elevated temperatures. The method provided a relatively simple and rapid means by which sodium sulfacetamide is quantitatively determined in the presence of its hydrolysis products, sulfanilamide and sodium acetate.

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