Copper-catalyzed dehydrogenative cross-coupling reaction between unactivated ethers and simple ketones mediated by pyrrolidine

Add time:09/26/2019    Source:sciencedirect.com

A copper-catalyzed dehydrogenative cross-coupling reaction between unactivated ethers and simple ketones mediated by pyrrolidine has been developed. Under the catalysis of CuBr2 and in the presence of pyrrolidine, either tetrahydrofuran 2a or tetrahydropyran 2b can react smoothly with a series of methyl aryl ketones 1a–m to give desired coupling products 3aa–mb using TBHP as an oxidant. The advantages of the dehydrogenative cross-coupling reaction are adoption of unmodified ethers as substrates, good tolerance of many functional groups and use of cheap copper salt as a catalyst. A plausible radical mechanism through enamine attack is proposed.

We also recommend Trading Suppliers and Manufacturers of di-m-tolyl ether (cas 19814-71-2). Pls Click Website Link as below: cas 19814-71-2 suppliers

Prev:An efficient and recyclable catalyst for the cleavage of tert-butyldiphenylsilyl ethers
Next:3.13 Oxidative Coupling of Phenols and Phenol Ethers)