Efficient synthesis of 2-trifluoromethyl quinolines via base-assisted propargyl-allenyl isomerization and aza-electrocyclization of trifluoromethylated alkynyl imines

Add time:09/26/2019    Source:sciencedirect.com

A mild and efficient base-mediated propargyl-allenyl isomerization and aza-electrocyclization reaction of trifluoromethylated alkynyl imines have been developed. This method provides a convenient access to 2-trifluoromethylated quinolines in high efficiency.

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