Effect of 1-Methyladenine (cas 1670-69-5) on double-helical DNA structures
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Add time:09/26/2019 Source:sciencedirect.com
Methylation at the N1 site of adenine leads to the formation of cytotoxic 1-Methyladenine (cas 1670-69-5) (m1A). Since the N1 site of adenine is involved in the hydrogen bonding of T·A and A·T Watson–Crick base pairs, it is expected that the pairing interactions will be disrupted upon 1-methylation. In this study, high-resolution NMR investigations were performed to determine the effect of m1A on double-helical DNA structures. Interestingly, instead of disrupting hydrogen bonding, we found that 1-methylation altered the T·A Watson–Crick base pair to T(anti)·m1A(syn) Hoogsteen base pair, providing insights into the observed differences in AlkB-repair efficiency between dsDNA and ssDNA.
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